Adverse Childhood Experiences and Treatment-Resistant Depression: Why Early Life Matters More Than We Think
Shyam Tailor
When Depression Does Not Respond: Looking Back to Move Forward
Treatment-resistant depression (TRD) remains one of the most challenging conditions in psychiatry. Despite multiple evidence-based treatments, many patients continue to experience persistent symptoms, functional impairment, and increased risk of suicidality.
A recent large-scale study published in JAMA Network Open provides compelling evidence that adverse childhood experiences (ACEs) play a significant and independent role in the...