Recurrent migraine with visual aura as the primary phenotype of familial neuronal intranuclear inclusion disease

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by highly heterogeneous clinical manifestations and multi-system involvement. The most common initial symptoms include tremor, cognitive impairment, and muscle weakness. Characteristic neuroimaging features comprise symmetrical diffusion-weighted imaging (DWI) high signal intensity in the corticomedullary junction and extensive leukoencephalopathy. NIID manifesting as migraine with visual aura as th