Target identification and assessment in the era of AI

Alex Zhavoronkov
Nature Reviews Drug Discovery, Published online: 20 April 2026; doi:10.1038/s41573-026-01412-8 Artificial intelligence (AI) is playing an increasingly important role in drug target identification and assessment, based on its proficiency in analysing large datasets and biological networks. This article reviews advances in the application of AI-driven approaches for therapeutic target exploration, and discusses how to address challenges and limitations in the field.