Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance
Boris Striepen
Nature Microbiology, Published online: 13 May 2026; doi:10.1038/s41564-026-02331-5 Forward and reverse genetics identifies the mode of action of clofazimine in the parasite Cryptosporidium. The genomic locus encoding the target is heterogeneous, and a resistance-conferring allele is already widely distributed.