Pulmonary & Respiratory Sciences - Juniper Publishers Abstract Idiopathic Pulmonary Fibrosis (IPF) presents a complex challenge in respiratory medicine, characterized by insidious onset and relentless progression. This comprehensive analysis delves into predictive biomarkers across diverse domains to enhance early detection, precise patient stratification, and personalized therapeutic interventions. Blood biomarkers, including Krebs von den Lungen-6 (KL-6) and Surfactant Proteins A and D (SP-A a