Accelerated biological aging based on DNA methylation clocks is a predictor of stroke occurrence: a systematic review and meta-analysis
Renli Deng
BackgroundAlthough traditional vascular risk factors, such as hypertension and diabetes, are incorporated into stroke risk prediction models, a significant proportion of stroke events remain unexplained by these models. Increasing evidence suggests that accelerated biological aging, as measured by DNA methylation clocks, may reflect reduced organ function and heightened susceptibility to disease. However, the relationship between epigenetic age acceleration (EAA) and stroke risk remains poorly u