Large-scale electrophysiology at single-spike resolution
Nicholas A. Steinmetz
Nature Reviews Neuroscience, Published online: 01 May 2026; doi:10.1038/s41583-026-01042-4 Recent advances in large-scale electrophysiology now enable researchers to record from thousands of neurons distributed across the brain. Siegle and Steinmetz describe the principles underlying this technology and outline the key considerations, challenges and opportunities associated with collecting, analysing and sharing large electrophysiological datasets.