Clinicopathological and immunohistochemical analysis of poorly differentiated squamous cell carcinoma and its impact on quality of life
Najwa Abdur Rashid
BackgroundPoorly differentiated squamous cell carcinoma (PDSCC) is an aggressive oral malignancy with rapid progression, high recurrence, and poor survival. This study aimed to evaluate the clinicopathological features, immunohistochemical expression of p63 and EGFR, and quality of life (QOL) in PDSCC compared to well-differentiated SCC (WDSCC).MethodsIn this retrospective observational study, 78 histopathologically confirmed OSCC cases (39 PDSCC and 39 WDSCC) from 2019–2025 were analyzed. Histo