Pooled CRISPRi screening reveals fungal-specific drug target candidates
Rebecca S. Shapiro
Nature Microbiology, Published online: 11 May 2026; doi:10.1038/s41564-026-02356-w This study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulnerabilities relevant to antifungal drug discovery.