Tools of the trade: leveraging 3D in vitro models to advance silicosis research
Elham Hosseini-Beheshti
Silicosis is an occupational fibrotic lung disease representing a major public health crisis, and places a significant burden on patients and healthcare systems. There are no curative treatments for patients with silicosis, and available anti-fibrotic agents have not been shown to reduce disease progression. Enhanced understanding of the cellular mechanisms governing silicosis is required to establish biomarkers of disease onset and progression to allow for early detection, timely intervention,