A spatially coordinated keratinocyte–fibroblast circuit recruits MMP9⁺ myeloid cells to drive type I interferon-driven inflammation in photosensitive autoimmunity
Manuel Garber
Nature Immunology, Published online: 24 April 2026; doi:10.1038/s41590-026-02502-w Wang, Afshari, Haddadi and colleagues compare UVB-sensitive and insensitive human skin diseases and show that photosensitive conditions, including cutaneous lupus erythematosus and dermatomyositis, have increased type I interferon activity and an expanded MMP9⁺CD14⁺ myeloid population that drives inflammation.