Stereoselective photometallobiocatalytic cross-coupling of organoboron reagents and diazo compounds via an outer-sphere mechanism
Yang Yang
Nature Catalysis, Published online: 29 April 2026; doi:10.1038/s41929-026-01532-9 Stereoselective radical C–C couplings remain a major challenge. Now photometallobiocatalytic cross-coupling of organotrifluoroborates and α-diazoesters is achieved with high enantio- and diastereoselectivity via an outer-sphere radical mechanism mediated by engineered cytochrome c and eosin B.