BackgroundKhaya senegalensis is a tree species that has traditional use for the alleviation of menstrual and hormonal symptoms in women. Moreover, supplementation with a Khaya senegalensis preparation (Khapregesic®) was associated with significant and rapid improvements in menstrual pain, mood, sleep, and fatigue in women with menstrual distress over 28 days. The present study aimed to assess the safety and efficacy of Khapregesic® over the same intervention period in women reporting menopausal