Single-crystal to single-crystal editing of metal–organic frameworks via ligand removal
Mohamed Eddaoudi
Nature Chemistry, Published online: 24 April 2026; doi:10.1038/s41557-026-02135-4 The synthesis of metal–organic frameworks (MOFs) featuring wide mesopores or specific topologies often relies on the use of additional ligands known as centring structure-directing agents (cSDAs). Now a single-crystal to single-crystal post-synthetic strategy for removing these cSDAs is reported, preserving MOF crystallinity while enabling topological transformations and enhanced porosity.