A Cu(I)-catalysed click reaction generates ROS-triggered cleavable linkages in aqueous media
Amir H. Hoveyda
Nature Chemistry, Published online: 24 April 2026; doi:10.1038/s41557-026-02100-1 The formation of functional linkages through click reactions is rare, and existing catalytic options do not provide a cleavable connector. Now a Cu(I)-catalysed click reaction (CuAKA) has been developed that is mutually orthogonal to CuAAC, operates in aqueous media and forms linkages that can be cleaved in <100 µM hydrogen peroxide.