MIT and Broad Institute researchers have developed U-STORM, a super-resolution microscopy platform using engineered upconverting nanoparticles that blink spontaneously and indefinitely. The method achieves 0.6-angstrom localization precision with a single near-infrared laser, enabling multicolor imaging without complex buffers or multiple lasers. This simplifies high-precision molecular imaging for biological applications. Published in Nature Nanotechnology.