Nature Reviews Drug Discovery, Published online: 29 May 2026; doi:10.1038/d41573-026-00083-9 Over the last decade, progress in science and technology has not only spurred biomedical innovation but has also led to an exponential growth in healthcare and regulatory data. When such data are carefully managed, they can inform medicines developers and regulators to further improve decision making and accelerate medicines innovation, to the benefit of patients.