Diet-induced metabolic memory shapes CD8 + T cell ferroptosis susceptibility
Whitney S. Henry
Nature Immunology, Published online: 13 April 2026; doi:10.1038/s41590-026-02493-8 Metabolic stress is associated with impaired immunity, yet underlying mechanisms remain unclear. Description of a xanthine-dependent antioxidant program that shields CD8+ T cells from ferroptosis reveals a metabolically actionable axis that control anti-tumor responses.