Deletion of Alg13 disrupts postnatal development and migration of GABAergic cortical interneurons
Peng Gao
BackgroundAbnormal cortical neuron development is closely associated with various neurological disorders. Deletion of the Alg13 gene has been identified as strongly associated with epilepsy susceptibility and seizure severity in mice. Similar deletions have also been observed in patients with epilepsy, indicating that Alg13 may play a critical role in cortical interneuron development.MethodsImmunofluorescence analysis was used to assess the effects of Alg13 deletion on the distribution and migra