Nature Communications, Published online: 12 June 2026; doi:10.1038/s41467-026-74186-7 The authors report a visible-light-mediated, chiral Brønsted acid-catalyzed C2-umpolung of 3-azoindoles, enabling their catalytic asymmetric formal nucleophilic C2-substitution with 2-substituted indoles. This strategy provides efficient access to axially chiral 2,3’-bisindoles in good yields with excellent enantioselectivities.