Nature Communications, Published online: 05 September 2026; doi:10.1038/s41467-026-77377-4 Organization and function of CNS synapses are instructed by synaptic cell adhesion molecules (sCAM). Here, authors show that the main sCAMs NRX and PTPRs are interlinked by the tetraspanins T178A,B, thus forming ternary complexes that serve as core-modules of transsynaptic networks.