iScience

Strategic, competitiveness-driven, and protectionist trade measures are reshaping global trade, while climate commitments face mounting urgency. This evolving policy landscape requires renewed scrutiny of the trade-climate nexus, as governments depart from liberalization and adopt interventions that affect trade and production patterns. This perspective offers a framework that integrates fragment…

Spermatogonial stem cells sustain spermatogenesis within a Sertoli cell-organized niche, yet xenogeneic spermatogenic differentiation after transplantation into host mouse seminiferous tubules has been reported in only a limited number of donor species. Here, we tested whether host niche engineering could support xenogeneic spermatogenic differentiation. Immunodeficient mouse testes were precondi…

Diagnosing rare diseases remains a major challenge due to limited clinical knowledge and the frequent absence of diagnostic criteria. We present a digital framework that leverages large language models and biomedical text embeddings to bridge this gap. By mapping Human Phenotype Ontology terms to a shared vector space with millions of PubMed abstracts and full-text articles, our method enables ph…

Understanding how surface morphology governs molecular adsorption remains a fundamental challenge in interfacial science. Here, inverse gas chromatography at infinite dilution is combined with a generalized five-parameter Lewis acid-base model to investigate adsorption on divinylbenzene-based copolymers. Statistical model discrimination demonstrates that nonlinear donor-acceptor coupling and curv…

Congenital heart disease (CHD) remains a major cause of pediatric morbidity and mortality, yet many patients lack a genetic diagnosis. Two studies identified rare deletions in ARHGAP10 (GAP10), a Rho GTPase-activating protein at 4q31.2 in individuals with heterotaxy and atrial septal defects, highlighting GAP10 as a new candidate CHD gene; however, the function of GAP10 has not been investigated.…

Ecological niche partitioning shapes microbial communities in terrestrial mosses, yet its underlying mechanisms and associated viral diversity remain poorly understood. Here, we characterized prokaryotic and viral communities in the rhizosphere soil (Rs) and endophytic niche (Pc) of Pogonatum cirratum using amplicon and metagenomic sequencing. Rs exhibited higher species richness, co-dominated by…

Thalassemias impose a substantial but highly uneven global health burden. Using Global Burden of Disease 2023 estimates, we quantified the prevalence, mortality, and disability-adjusted life years (DALYs) of thalassemias across 204 countries and territories from 1980 to 2023 and evaluated health system performance with frontier analysis. Although the global age-standardized DALY rate declined by …

Utilities must incorporate electric vehicle (EV) charging demand alongside variable generation. Early EV adopters relied on home charging, creating evening loads poorly aligned with solar. Existing demand-side management strategies often rely on time-of-use pricing or automated control, which can limit equitable access. As public charging is deployed, location selection may support charging when …