World Journal of Psychiatry

Post-stroke depression (PSD) has a stable prevalence of 30%. Beyond stroke severity, lesion location and prior depression, vitamin D deficiency, hyperhomocysteinaemia and insulin resistance are now recognised as independent risk factors. Mechanistically, phenotypic switching of microglia and astrocytes drives neuro-inflammation via NF-κB, JAK-STAT3 and NLRP3 inflammasome signalling. Gut-brain axi…

BACKGROUND Patients with spinal cord injury (SCI) commonly experience varying degrees of anxiety, depression, and sleep disturbances, which may hinder postoperative recovery. AIM To examine the association between postoperative anxiety-depression symptoms, injury severity, and sleep quality in patients with SCI. METHODS A total of 149 patients who underwent surgical treatment for SCI from Decembe…

BACKGROUND Laparoscopic surgery is the standard minimally invasive treatment for pediatric appendicitis. However, children with appendicitis may experience varying degrees of anxiety and depression due to the illness itself and the surgical procedure, which is not conducive to a smooth postoperative recovery. AIM To assess whether adding psychological intervention to standard operating room nursi…

BACKGROUND Patients with colorectal cancer (CRC) frequently experience significant anxiety and depression during the perioperative period. Such psychological distress can adversely affect postoperative pain, recovery trajectory, and quality of life. However, evidence supporting the efficacy of structured perioperative psychological nursing interventions remains limited. We hypothesized that targe…

BACKGROUND Chronic respiratory diseases (CRDs), such as chronic obstructive pulmonary disease and asthma, impose significant physical and psychological burdens on patients. Effective management requires medical treatment and psychological support to improve treatment compliance and overall well-being. AIM To improve the psychological care and compliance management of patients with CRDs. METHODS P…

BACKGROUND Congenital microtia is a common craniofacial malformation in children that not only affects facial appearance but also has substantial psychological effects. The emotional consequences of auricle deformities are increasingly recognized in affected children. AIM To optimize perioperative nursing for patients undergoing total auricular reconstruction by examining the impact of comprehens…

BACKGROUND Perioperative anxiety and depression are common, yet often underestimated psychological comorbidities in patients undergoing transurethral urological surgery. These emotional disturbances can negatively affect anesthesia induction, hemodynamic stability, postoperative pain, and recovery. The choice of anesthetic technique and adjunctive psychological intervention may have influenced th…

Esophageal cancer (EC) is one of the most lethal cancers of the digestive tract, characterized by rapid progression, high recurrence, and poor survival rates despite advancements in treatment. Its tendency to metastasize to bone increases the disease burden by causing severe pain, disability, and psychological distress. The psychological distress, which frequently remains unrecognized, is a dimen…

BACKGROUND Postoperative delirium (POD) is characterized as a major complication for the geriatric population, and is associated with worsening of the individual and an increase in healthcare costs. The association between POD and the presence of preoperative depression and cognitive status remains unknown. AIM To analyze whether preoperative cognitive status and depression would associate with P…

BACKGROUND Adolescence and early adulthood are critical periods for mental health in footballers, during which competitive demands such as performance expectations, training load, and competitive pressure may negatively affect psychological well-being. In football, these demands can lead to emotional deterioration throughout the season, underscoring the need for cognitive behavioural intervention…

BACKGROUND Among stroke patients, post-stroke depression (PSD) represents a frequent complication that substantially impacts neurological rehabilitation and quality of life. While vascular risk factor clustering might serve as a crucial predictor for PSD development, the specific mechanisms underlying its influence remain incompletely understood. AIM To examine how vascular risk factor clustering…

BACKGROUND Depression in elderly patients with chronic diseases is a prevalent issue exacerbated by insufficient social support and traditional care models. While social support and rehabilitation nursing are recognized as beneficial, their integration under a motivational framework remains underexplored. Advocacy-promotion theory offers a structured approach to empower patients and mobilize mult…

BACKGROUND Body image disturbance is a common psychosocial issue among patients with breast cancer, leading to stigma that negatively impacts their psychological well-being and quality of life. Resilience and social support are the key protective factors that may buffer this relationship. Previous studies have explored these constructs separately, but little is known about their potential chain-m…

BACKGROUND The hypothalamic suprachiasmatic nucleus, as the master circadian pacemaker, coordinates circadian homeostasis via neuroendocrine signaling networks. Circadian rhythm disruption (CRD) denotes functional impairment of this system, driven by etiologies ranging from environmental stressors to intrinsic insults, triggering pathophysiological cascades. AIM To delineate neuroendocrine-immune…

BACKGROUND Restless abdomen is a rare phenotypic variant of restless legs syndrome (RLS), characterized by visceral discomfort and an urge to move localized to the abdominal region. Due to its atypical presentation, it is frequently misdiagnosed as a primary psychiatric or functional gastrointestinal disorder, leading to ineffective management. CASE SUMMARY We report the case of a 55-year-old fem…

BACKGROUND Conventional treatments for thyroid nodules (TNs), whether based on Western medicine or limited to emotional regulation, diet, and lifestyle adjustments, have shown modest effectiveness. AIM To evaluate the efficacy of Jianpi Huazhuo Xiaoying Decoction (JPHZXYD), a formula designed to strengthen the spleen, resolve turbidity, and disperse nodules, combined with emotional conditioning t…

BACKGROUND Patients with advanced cancer frequently experience significant psychological distress, which is often inadequately addressed by standard palliative care. Although humanistic care, an approach emphasizing respect for patient values, dignity, and individualized emotional support, is widely endorsed, its benefits, especially for those diagnosed with advanced cancer, remain unclear. AIM T…

BACKGROUND Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and their caregivers increasingly turn to artificial intelligence-based chatbots for information about symptoms, functional difficulties, and treatment-related concerns. Large language models (LLMs), such as ChatGPT, are of particular interest due to their ability to generate fluent, natural-language response…

BACKGROUND Although total joint arthroplasty effectively treats end-stage joint diseases, 10%-30% of patients experience poor outcomes. Preoperative anxiety and depression are common, but their long-term prognostic impact remains unclear. This study aimed to investigate the association between preoperative anxiety/depression and two-year outcomes after total hip or knee arthroplasty. AIM To evalu…

BACKGROUND Patients with major depressive disorder (MDD) commonly exhibit widespread cognitive impairments. Music, as a complex auditory stimulus with relatively high ecological validity, can be utilized to investigate brain information processing mechanisms. Event-related potentials (ERPs) are well-suited for capturing the temporal dynamics of neural processing across successive cognitive stages…