BACKGROUND The hypothalamic suprachiasmatic nucleus, as the master circadian pacemaker, coordinates circadian homeostasis via neuroendocrine signaling networks. Circadian rhythm disruption (CRD) denotes functional impairment of this system, driven by etiologies ranging from environmental stressors to intrinsic insults, triggering pathophysiological cascades. AIM To delineate neuroendocrine-immune circuits in female textile workers with CRD by integrating diffusion spectrum imaging (DSI)-based ne