Angewandte Chemie

ABSTRACT Smart windows that function in response to external conditions provide a promising approach to reduce heating, ventilation, and air conditioning energy consumption. However, it remains a major challenge to develop a smart window with environmental adaptability, multiple working states, and most importantly, the ability of dynamic management of solar light and heat with a simple and versa…

ABSTRACT The insertion of five‐membered heteroarenes into the C─C bonds of benzocyclobutenones (BCBs) has been achieved. This process proceeds under mild conditions and does not require the use of a transition metal catalyst. A variety of fused polycyclic compounds based on indoles, 7‐azaindoles, benzothiophenes, benzofurans, and thiophenes relevant to bioactive scaffolds are efficiently accessed…

ABSTRACT Phenols are abundant aromatic feedstocks widely used in organic synthesis and are commonly obtained from lignin and other renewable resources. However, the functionalization of their inert C(sp 2 )─OH bonds remains a formidable challenge, often necessitating additional preactivation steps or harsh reaction conditions. Here, we report an electrochemical strategy that enables the cleavage …

ABSTRACT Accessing structurally well‐defined polymer polymorphs remains extremely challenging because obtaining polymer single crystals suitable for atomic‐level structural characterization is rare. Here we report an unusual sequence of single‐crystal transformations in which a peptide monomer designed for topochemical azide–alkyne cycloaddition (TAAC) undergoes spontaneous single‐crystal‐to‐sing…

ABSTRACT Intrinsic luminescence in polymer hydrogels is highly desirable for soft optoelectronic and information‐security applications, yet remains difficult to achieve under hydrated conditions, where clusterization‐triggered emission (CTE) is easily quenched by water due to disrupted intermolecular interactions. Here, we establish a facile and general strategy to overcome this limitation via di…

ABSTRACT Proton batteries are emerging as a promising next‐generation energy storage technology, featuring high safety, superior power density, and excellent stability. However, the development of solid‐state electrolytes with high proton conductivity remains a significant challenge. Herein, graphdiyne oxide (GDYO) is proposed as a novel solid‐state electrolyte for proton batteries for the first …

ABSTRACT Various Ni‐based metalloenzymes employ synergistic heterometallic cooperativity where a Ni center and a second metal ion cofacilitate small‐molecule conversion. Inspired by these biological systems, synthetic model complexes have been developed that exploit bimetallic cooperativity to achieve analogous reactivity. In this work, we report a bimetallic Ni−Zn complex comprising a pincer‐typ…

ABSTRACT Platinum(II) complexes bearing aromatic ligands have garnered extensive attention as they exhibit highly efficient, stimulus‐responsive luminescence originating from the triplet metal–metal‐to‐ligand charge transfer state when stacked, which enables electronic interactions between platinum ions. However, achieving full‐color luminescence changes in a single system through external stimul…

ABSTRACT Pharmacological intervention is a primary therapeutic strategy for Osteoarthritis (OA), however, improving the bioavailability of therapeutic agents remains a significant challenge. In this study, we developed oxygen‐propelled, glutathione (GSH)‐responsive stomatocyte nanomotors (MTX/MnO 2 ‐GSH‐stomatocytes) for osteoarthritis (OA) treatment. First, polymersomes were assembled composed o…

ABSTRACT Electron‐transfer‐involved persulfate‐based advanced oxidation processes (ET‐AOPs) are attractive for wastewater treatment because of their high selectivity and environmental robustness. However, ET‐AOPs are intrinsically dual‐site reaction requiring efficient electron transfer between persulfate‐binding and pollutant‐binding sites. This constraint is often obscured in powder catalysts b…

ABSTRACT This review is an update of our previous contribution published in Angewandte Chemie in January 2019 and provides a critical analysis of the overall scientific production and key findings from NMR‐based metabolomics between January 2018 and April 2025. We developed a strategy (described in the Methodological Approach section) for systematically analyzing the literature that enabled us to…

ABSTRACT The integration of ligand and strain effects in core/shell architectures offers a compelling avenue for boosting the catalytic efficiency of noble metals. However, conventional thin‐Pt‐shell catalysts incorporating small‐radius transition metals suffer from an over‐compressed Pt lattice, leading to limited oxygen reduction reaction (ORR) performance toward fuel cell devices. Herein, we r…

ABSTRACT Surface defects such as iodine vacancies initiate lattice degradation via I − migration and proton transfer, resulting in structural collapse. This degradation propagates into the bulk via coupled ion and vacancy diffusion, thereby accelerating irreversible performance decay. Conventional surface‐passivation methods are often limited by weak intermolecular interactions and suboptimal sta…

ABSTRACT Achieving organic phosphorescence that remains stable at elevated temperatures is challenging because thermally activated molecular motions typically accelerate non‐radiative decay of triplet excitons. Here, we report a topology‐driven conformational constraint strategy to enable high‐temperature organic phosphorescence. A hydrogen‐bonded supramolecular framework constructed from melamin…

ABSTRACT Redox‐buffering systems in tumors heighten chemoresistance, yet most ROS‐responsive linkers used in prodrug design consume oxidants, exhibit limited sensitivity to endogenous ROS, and often require external triggers or complex formulations, constraining clinical translation. Here we report a phenylselanyl cyclohexenone self‐immolative linker that couples ROS‐triggered cleavage with organ…

ABSTRACT Covalent organic framework (COF) materials with molecule‐level functionality show great promise as anode materials for K‐ion batteries (KIBs). However, their practical application is hindered by limited capacity and poor cycling stability, especially under extreme temperatures. These issues stem from the large ionic size of K + and thermally induced electrochemical degradation. Herein, w…

ABSTRACT Photocatalytic H 2 O 2 generation is hindered by low concentrations and energy‐intensive purification, posing major barriers to practical application. Herein, a tandem catalytic strategy that integrates H 2 O 2 generation with its in situ utilization in organic synthesis is reported to overcome these constraints. Covalent organic frameworks (COFs) engineered through a “docking and lockin…

ABSTRACT The electrochemical nitrogen reduction reaction (NRR) offers a sustainable transformation of nitrogen (N 2 ) into highly valuable ammonia. However, achieving both a high ammonia yield and an Faradaic efficiency (FE) higher than 40% at practical current density remains challenging, particularly with bulk metal catalysts. Herein, we propose a shell‐protection strategy to successfully prepa…