ABSTRACT The integration of ligand and strain effects in core/shell architectures offers a compelling avenue for boosting the catalytic efficiency of noble metals. However, conventional thin‐Pt‐shell catalysts incorporating small‐radius transition metals suffer from an over‐compressed Pt lattice, leading to limited oxygen reduction reaction (ORR) performance toward fuel cell devices. Herein, we report a class of PdSn/PtSn/Pt sandwich‐structured nanowires based on large‐radius Sn elements, taking