Nature Communications

Abstract Squeezed light enables quantum-enhanced phase estimation, with crucial applications in both fundamental physics and emerging technologies. To fully exploit the advantage provided by this approach, estimation protocols must remain optimal across the entire parameter range and resilient to instabilities in the probe state. In this context, strategies that rely on pre-calibrated squeezing l…

Abstract Oropouche virus (OROV) is an emerging orthobunyavirus responsible for widespread outbreaks across South and Central America. Recent reports of congenital disease have raised urgent concerns regarding the potential risk of OROV infection during pregnancy. Here, we establish an in vivo murine model of OROV vertical transmission using the ancestral (prototype) strain BeAn19991 in immunocomp…

Abstract Evidence is needed for single-dose human papillomavirus (HPV) vaccine efficacy (VE) durability to support vaccination guidelines. In this randomized crossover trial (NCT03675256), healthy young women aged 15-20 years, recruited through community-based screening in Kenya, were randomly allocated to immediate nonavalent or bivalent HPV vaccination and delayed control at month 30/36 (age 17…

Abstract Sialic acids cap the ends of many glycan chains and play pivotal roles in cell signaling, immunity, and pathogen interactions. However, the fast synthesis of sialylated glycans by automated glycan assembly (AGA) has remained a long-standing challenge. Here we show a general strategy that leverages macrobicyclic sialic acid building blocks to achieve reliable α(2,3)- and α(2,6)-sialylatio…

Abstract The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited settings threaten treatment access. Cost-effective and widely available prevention strategies, such as oral emtricitabine/tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF-PrEP), are therefore essential. C…

Abstract The placenta is essential for fetal development, yet its molecular evolution across mammals remains elusive. Here, we present a comprehensive single-cell transcriptomic atlas of ~300,000 cells from ten species representing the four primary placental types: discoid, cotyledonary, diffuse, and zonary. Our cross-species analysis identifies trophoblast lineages as the primary drivers of plac…

Abstract Menin inhibitors have entered clinical trials for histone lysine methyltransferase 2 A (KMT2A) -rearranged and nucleophosmin 1 (NPM1) -mutant acute leukemias and are demonstrating promising activity. CRISPR base editor screening previously predicted several MEN1 (menin) mutations that have arisen in patients receiving SNDX-5613 and confer resistance. The extent to which MEN1 mutations wi…

The UV/sulfite system is currently regarded as the most effective method for degrading and defluorinating per- and poly-fluoroalkyl substances (PFAS), operating via hydrated electrons (eaq−). Previous studies largely concentrate on PFAS molecular structure, overlooking the critical influence of eaq− microstructure. By integrating ab initio molecular dynamics simulations with experiments, we revea…