Journal of Medical Case Reports

Abstract Background Chronic venous ulcers (CVUs), affecting 1–5% of adults, present significant management challenges due to delayed healing and high recurrence rates. Negative pressure wound therapy (NPWT) has emerged as a beneficial adjunct to compression therapy for refractory cases. Case presentation A 78-year-old Chinese female with a 30-year history of symptomatic bilateral varicose veins C…

Developmental epileptic encephalopathy (DEE) is a severe neurodevelopmental disorder characterized by developmental delay, regression, and intractable seizures. Genetic testing plays a crucial role in identifying underlying pathogenic variants, guiding treatment, and improving patient outcomes, particularly in resource-limited settings. A one-and-a-half-year-old Sri Lankan boy was assessed due to…

Colovesical fistula (CVF) typically manifests with pneumaturia or fecaluria and is diagnosed promptly. We present an exceptionally rare and severe manifestation of CVF resulting from a 10-year diagnostic delay, which culminated in extraordinary complications, scarcely documented in contemporary literature. A 42-year-old Arab male from Syria was diagnosed with a colovesical fistula (CVF) after 10-…

Intracerebral hemorrhage in the postpartum period is an uncommon but potentially life-threatening condition. Hypertensive disorders of pregnancy remain the most frequent cause. However, rare case reports have described intracranial bleeding occurring after neuraxial anesthesia. However, the coexistence of multiple confounding factors, including hypertensive crises, individual cerebrovascular vuln…

In our clinical practice, we encountered a patient with autism spectrum disorder (ASD) and comorbid narcolepsy who developed dyskinesia following the administration of modafinil for excessive daytime sleepiness. Modafinil is widely prescribed as a wakefulness-promoting agent for the treatment of narcolepsy. Although dyskinesia has been reported as a potential adverse effect of modafinil, to our k…

Neuroblastoma is a rare, aggressive childhood malignancy originating from neural crest progenitor cells of the sympathetic nervous system. While primarily a pediatric tumor, adult-onset neuroblastoma poses significant diagnostic and therapeutic challenges owing to its rarity, absence of standardized treatment protocols, and poor response to therapy. This case highlights a unique presentation of r…

This report presents a case of recurrent chondrosarcoma in the maxilla of a young woman and discusses the diagnostic challenge with chondroblastic osteosarcoma. It emphasizes the need for long-term follow-up in managing this malignancy.

Although uterine angioleiomyoma is rare, it should be suspected if radiological investigation reveals a multilobulated mass with solid, cystic, and multi-septal content in middle-aged women. The good outcome further strengthens the role of proper surgical care and follow-up histology in patients with symptomatic gynecological abdominal tumors.

This case highlights the rarity of posterior auricular seborrheic keratosis and underscores the importance of histopathological confirmation in lesions with indeterminate clinical features. The bilobed flap provided reliable coverage for a relatively large auricular defect, achieving favorable cosmetic and functional results. Documentation of such uncommon cases contributes to improved diagnostic…

This case highlights the diagnostic challenge of cystic neutrophilic granulomatous mastitis, particularly when imaging strongly suggests carcinoma. It emphasizes the indispensable role of histopathology and the need for multidisciplinary management to avoid overtreatment.

Our cases demonstrate that Lyme neuroborreliosis patients with symptom duration for several weeks and a well-functioning immune system can present with atypical antibody profiles. Consequently, we suggest that in cases with pleocytosis and symptoms compatible with Lyme neuroborreliosis but negative Borrelia burgdorferi antibody index, one should consider supplementary laboratory testing to confir…

Case reports such as this emphasize the importance of including peripheral extraosseous ameloblastoma in the differential diagnosis of oral soft-tissue growths to ensure accurate identification and management.

Odontoid fracture without direct trauma, although uncommon, must be suspected when a patient complains of severe pain in the neck and shoulder following a generalized tonic-clonic convulsion. A high index of suspicion and anticipated cervical immobilization are required to avoid devastating neurological complications.