Combined conservative hemodynamic treatment for venous insufficiency strategy and negative-pressure wound therapy for the management of a refractory venous ulcer: a case report and review of the literature

Abstract Background Chronic venous ulcers (CVUs), affecting 1–5% of adults, present significant management challenges due to delayed healing and high recurrence rates. Negative pressure wound therapy (NPWT) has emerged as a beneficial adjunct to compression therapy for refractory cases. Case presentation A 78-year-old Chinese female with a 30-year history of symptomatic bilateral varicose veins CEAP C6 (CEAP classification stands for Clinical (C), Etiological (E), Anatomical (A), and Pathophysio