Journal of Radiation Research and Applied Sciences

Investigating the antiemetic effect of HWZO and the underlying molecular mechanism of its antiemetic effect. CINV models of rats and cells were constructed using cisplatin and substance P, respectively. The intake of kaolin observed the antiemetic effect of HWZO. Effective cell concentrations of HWZO were screened, and 5-HT3R knockdown and overexpression cell lines were constructed. The expressio…

Effective therapies to halt diabetic nephropathy (DN) progression are needed. Finerenone mitigates renal inflammation and fibrosis, while Compound α-Ketoacid Tablets reduce renal metabolic load. This study evaluated the synergistic renoprotective effect of their combination and assessed renal drug targeting using radionuclide imaging in type 2 DN. In this study with a hybrid design (n = 220), pat…

Natural radioactivity in food products contributes to long-term internal radiation exposure and remains an important aspect of radiological food safety assessment. This study evaluates the activity concentrations of naturally occurring radionuclides ( 226 Ra, 232 Th, and 40 K) in coffee beans cultivated in southern Saudi Arabia and compares them with selected imported samples from Ethiopia and Ch…

Dimethomorph (DMM), a widely used morpholine fungicide, poses emerging concerns for reproductive health due to its environmental persistence and anti-androgenic activity. However, pregnancy-specific hepatotoxicity mechanisms remain uncharacterized. Here, we present the first single-cell resolution map of DMM-induced hepatic disruptions in pregnant mice, integrating scRNA-seq with untargeted metab…