Single-cell and metabolomic profiling reveals multi-lineage hepatic perturbations and metabolic reprogramming in pregnant mice exposed to dimethomorph

Dimethomorph (DMM), a widely used morpholine fungicide, poses emerging concerns for reproductive health due to its environmental persistence and anti-androgenic activity. However, pregnancy-specific hepatotoxicity mechanisms remain uncharacterized. Here, we present the first single-cell resolution map of DMM-induced hepatic disruptions in pregnant mice, integrating scRNA-seq with untargeted metabolomics. DMM exposure (180 mg/kg/day, GD7–birth) caused synchronized downregulation of oxidative phos