Hewei Zhiou Recipe relieves CINV through the 5-HT3R/SERT signaling pathway

Investigating the antiemetic effect of HWZO and the underlying molecular mechanism of its antiemetic effect. CINV models of rats and cells were constructed using cisplatin and substance P, respectively. The intake of kaolin observed the antiemetic effect of HWZO. Effective cell concentrations of HWZO were screened, and 5-HT3R knockdown and overexpression cell lines were constructed. The expression levels of essential markers related to 5-HT and substance P in serum, ileum, and medulla oblongata