JNCI Journal of the National Cancer Institute

Asian American females-especially those of Chinese, Japanese, and South Asian descent-had better survival than non-Latina NLW females. Disaggregating Asian American ethnicities clarifies survival differences and may inform research on personal, social, and lifestyle factors to benefit all patients.

Phase 1 trials are primarily discontinued for "sponsor/strategic decisions". Funding source, tumor type, and geographic location of recruiting centers are independently associated with ET. The early peak in ET probability marks a critical window for interventions to improve trial sustainability.

We calculated age-standardized cervical cancer incidence rates and trends by histologic type among women aged 15-29 years, using cancer registry data covering approximately 99% of the United States population. We examined differences in incidence rates from the earliest to the most recent study period and quantified changes over time using joinpoint regression. Incidence rates for cervical squamo…

Almost half of FDA approved pediatric indications for oncology therapeutics were supported by data from COG trials, highlighting the effectiveness of this public-private partnership model in producing the level of clinical evidence required for regulatory success.

MIRAI demonstrated stronger discriminatory accuracy than clinical models for five-year overall and invasive bc risk prediction but overestimated risk for both bc endpoints. AI-based risk models should consider discriminatory accuracy and calibration for invasive cancer before implementation.

The National Cancer Institute (NCI) awarded administrative supplements to 11 NCI-designated cancer centers to build capacity for financial navigation services and collect preliminary data to implement and evaluate financial navigation programs. Preliminary findings from the projects were shared during a virtual conference in October 2022. This paper reflects major themes from the conference, the …

Adherence to antidepressants could potentially reduce recurrence in patients with breast cancer and MDD.

≥5-year DLBCL survivors have increased risks of developing CVDs, especially HF. Physicians and patients should recognize this risk, and individualized cardiac screening should be considered.

Understanding long-term trends in cancer mortality in rural and urban areas can provide additional insight into factors contributing to rural-urban disparities in cancer mortality and inform public policies. We examined trends in age-standardized cancer mortality rates (overall, lung, colorectal, female breast, and prostate cancers) by urbanicity of county of residence using National Center for H…

OP-35 showed poor agreement with clinicians for avoidable hospital visits, raising concerns about its clinical validity. An alternative classification system grouping visits into actionable clinical scenarios offered superior diagnostic accuracy.

MHT in women may decrease the risk of hepatocellular carcinoma, but not intrahepatic cholangiocarcinoma.

Beta-blocker use was associated with improved OS and PFS in patients with solid cancers.

Exposure to PAHs, TSNAs and several VOCs through tobacco smoking were associated with increased lung cancer risk among women.

SDOH Z-codes are rarely submitted with billing claims for Medicare patients with cancer. Whether Z-codes reflect the social needs of patients with cancer remains unclear. With current coding, any SDOH Z-code is associated with poor survival in these patients, but individual Z-codes are not consistently associated with survival. Further studies should determine whether SDOH Z-codes enable effectiv…

Survival at restaging after neoadjuvant chemotherapy of patients with localized PDAC is determined by eight patient, tumor and treatment response characteristics. A web-based calculator can inform clinicians and patients about individualized prognosis and guide further management.

GPVs in BRCA1, BRCA2, ATM, CHEK2, and PALB2 are associated with distinct intrinsic breast cancer subtypes and somatic genomic alterations. These findings may enhance precision in risk stratification and guide personalized treatment strategies.

Adherence to healthy dietary patterns, especially AHEI and AMED, after prostate cancer diagnosis was associated with improved survival, particularly in less aggressive disease. These findings support dietary improvement as a part of survivorship care.