Landscape of somatic genetic alterations and PAM50 intrinsic subtypes in breast cancer associated with germline pathogenic variants in DNA-repair genes
Siddhartha Yadav·Tuya Pal·Padma Sheila Rajagopal·Ali T. Arafa·Emily A. Teslow·Jennifer G. Whisenant·Minxuan Huang·Stamatina Fragkogianni·Sonya Reid·Elizabeth Mauer·Emmanuel S Antonarakis·Calvin Chao·Allison Kurian·Anne Weidner·Fergus J Couch·Binyam Yilma
GPVs in BRCA1, BRCA2, ATM, CHEK2, and PALB2 are associated with distinct intrinsic breast cancer subtypes and somatic genomic alterations. These findings may enhance precision in risk stratification and guide personalized treatment strategies.