Journal of Translational Medicine

Abstract Background Osteosarcoma remains a highly aggressive bone malignancy with limited therapeutic progress in metastatic and treatment-refractory disease. Beyond tumor-intrinsic drivers, the tumor microenvironment has emerged as a critical determinant of immune escape, therapeutic resistance, and poor clinical outcome. Among stromal components, cancer-associated fibroblasts (CAFs) are increas…

Abstract Dry eye disease (DED) is a prevalent multifactorial ocular surface disorder. Early research primarily attributed its pathogenesis to insufficient tear secretion or excessive tear evaporation. Advances in mechanistic research have shifted the academic understanding from a narrow tear film-centric perspective toward an integrated framework of disrupted overall ocular surface homeostasis. C…

ABSTRACT Cardiovascular disease (CVD) remains a leading cause of death worldwide. Dilated cardiomyopathy (DCM), a major cause of heart failure (HF), exhibits ventricular dilation, impaired systolic/diastolic function, arrythmias, and adverse cardiac remodeling. While genetic causes of DCM have been extensively studied, non-genetic and acquired forms of DCM-like HF are less well characterized, esp…

Abstract Background Cirrhosis-associated matrix stiffness is a major biophysical driver of hepatocellular carcinoma (HCC). How fibrosis-induced stiffness activates oncogenic YAP signaling remains unclear. We investigated the role of ficolin-3 (FCN3) in stiffness-associated regulation of the O-GlcNAc transferase (OGT)–YAP axis in HCC. Methods Public transcriptomic datasets comparing cirrhotic and …

The limited clinical success of anticancer therapies highlights the need for preclinical models that more accurately recapitulate tumor complexity, therapeutic response, and patient-specific heterogeneity. Conventional two-dimensional (2D) culture systems fail to capture the structural organization, cellular diversity, and dynamic microenvironmental gradients of in vivo tumors, thereby limiting t…

Abstract Background Primary aldosteronism (PA) is a major cause of endocrine hypertension and contributes substantially to blood pressure (BP)-related morbidity. Although aldosterone excess directly raises BP, the extent to which genetic susceptibility to PA overlaps with the broader polygenic architecture of BP remains unclear. We aimed to characterise the shared genetic architecture between PA …

Mitochondria are recognized as pivotal regulators in cell fate determination, and their dysfunction is implicated in numerous major diseases. While mitochondria control classical programmed cell death pathways, including apoptosis, necroptosis, and pyroptosis, the recent identification of mitoxyperiosis, a BAX/BAK1/BID-dependent and spatially restricted mode of oxidative death, has added complexi…