BMC Psychiatry

Abstract Background Pharmacogenomic (PGx) testing holds promise for personalized psychiatry, but its clinical utility in real-world inpatient settings remains inadequately established. Using real-world data, this study investigated whether PGx testing is associated with improved treatment outcomes in hospitalized patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar diso…

The rising number of pediatric intensive care unit (PICU) admissions has brought post-traumatic stress disorder (PTSD) into sharp focus as a pressing mental health concern among pediatric patients. This study aimed to explore the PTSD-related experiences of children following PICU hospitalization. This descriptive qualitative study investigated PTSD-related experiences in children aged 8–18 years…

The raphe nuclei, the principal sources of serotonergic projections, are central to emotional processing and reward regulation. Since altered raphe nucleus function is implicated in depression, we mapped voxel-based functional connectivity (FC) of the dorsal (DRN) and medial raphe nucleus (MRN). This study aimed to investigate FC alterations in depressed adolescents, to determine their associatio…

Previous studies have reported protective effects of self-compassion and a growth mindset on youth suicidality. This study aimed to understand the mediating role of self-compassion and a growth mindset in the effects of intraindividual, behavioural, family, and school risk factors on youth suicidality under an ecological framework. A school-based survey was conducted in four primary schools and 1…

It has been reported that self-harm behaviour and suicidal ideation are more prevalent among adolescents with gender dysphoria compared to the general adolescent population. However, studies examining whether these risk behaviours differ according to sex assigned at birth are limited. This study aimed to investigate whether self-harm behaviour, suicidal ideation, and severity of suicidal behaviou…

The COVID-19 pandemic had extensive psychological and social impacts, including increased anxiety, depression, and mental health disorders. Social restrictions and reduced access to healthcare services have further exacerbated mental health issues. This study aims to investigate the immediate and long-term impact of the COVID-19 pandemic on utilization patterns of mental health services in Iran i…

Abstract Background This exploratory study aimed to compare frailty characteristics between patients with schizophrenia and healthy controls, and to investigate the association between frailty severity and immune-inflammatory markers in individuals with schizophrenia. Methods We recruited 27 community-dwelling patients with schizophrenia (mean age 39.9 ± 7.8 years) and 14 age-matched healthy cont…

Despite increasing attention to autism caregiving, the emotional and relational experiences of fathers remain insufficiently understood. This study explores how caregiving shapes fathers’ emotional experiences, close relationships, and paternal identity within the context of autism. This qualitative descriptive study draws on 14 in-depth interviews with fathers actively involved in raising autist…

Suicidal behavior is not the result of a single cause or event, but rather reflects interacting clinical and psychosocial factors. Potential facilitators include dissociation and self-hate. This study assessed the association between a tailored psychoeducational program and changes in self-loathing, dissociation, and suicidal behavior among patients with psychiatric disorders. A quasi-experimenta…