Raphe subregion seeds reveal whole-brain functional connectivity differences underlying adolescent depression

The raphe nuclei, the principal sources of serotonergic projections, are central to emotional processing and reward regulation. Since altered raphe nucleus function is implicated in depression, we mapped voxel-based functional connectivity (FC) of the dorsal (DRN) and medial raphe nucleus (MRN). This study aimed to investigate FC alterations in depressed adolescents, to determine their associations with clinical symptoms, and to evaluate the potential of these FC metrics to identify adolescents