Metabolic Brain Disease

Alzheimer’s disease (AD), a neurodegenerative, irreversible, and progressive brain disorder, is characterized by memory loss and cognitive dysfunction. In neurodegeneration, gut microbiota and their metabolites have an impact on behavior and brain function. This study aimed to identify fecal candidate discriminant metabolites in 5XFAD mice assosciated with AD as compared to an age-matched wild-ty…

Chronic stress induces sensorimotor, cognitive, and neuroendocrine alterations, particularly in females who exhibit heightened vulnerability to stress-related disorders. This study tested the hypothesis that chronic quetiapine administration during ongoing unpredictable chronic mild stress (UCMS) would attenuate stress-induced impairments in sensorimotor gating, recognition memory, and HPA-axis–r…

Cerebral ischemia, resulting from acute interruption of cerebral blood flow, is a leading cause of long-term cognitive and motor disabilities, and current therapeutic options remain limited. Decanoic acid, a medium-chain fatty acid with antioxidant and anti-inflammatory properties, has been proposed as a potential neuroprotective agent. This study evaluated the neuroprotective and metabolic effec…