A perspective for alzheimer disease from gut microbiota-associated NMR-based fecal metabolomics: a study with 5XFAD mice
Nazlıhan Tekin·Ahmet Tarık Baykal·Betül Şahin·Zelal Zuhal Kaya·Ali Yılmaz·Stewart F. Graham·Mustafa Serteser·Furkan Şahin
Alzheimer’s disease (AD), a neurodegenerative, irreversible, and progressive brain disorder, is characterized by memory loss and cognitive dysfunction. In neurodegeneration, gut microbiota and their metabolites have an impact on behavior and brain function. This study aimed to identify fecal candidate discriminant metabolites in 5XFAD mice assosciated with AD as compared to an age-matched wild-type (WT) healthy mice groups at three different time points (3, 6, and 9 month) using Proton Nuclear M