Decanoic acid modulates cerebral metabolism and attenuates ischemic injury in a mouse model
Antonio Ítalo Santos Nunes·Mauro Cunha Xavier Pinto·Nelson Roberto Antoniosi Filho·Jacqueline Alves Leite·Gustavo Almeida de Carvalho·Lurian Caetano David·Eduardo Rosa Silva·Daniel Pereira Cavalcante
Cerebral ischemia, resulting from acute interruption of cerebral blood flow, is a leading cause of long-term cognitive and motor disabilities, and current therapeutic options remain limited. Decanoic acid, a medium-chain fatty acid with antioxidant and anti-inflammatory properties, has been proposed as a potential neuroprotective agent. This study evaluated the neuroprotective and metabolic effects of decanoic acid in a murine model of permanent middle cerebral artery occlusion (MCAO). Male mice