Preprints.org

Semaglutide and tirzepatide are typically evaluated through dose escalation, yet many patients in routine care do not reach a recommended maintenance dose due to tolerability, access, cost, supply or individualized goals. Here we used sustained 0.25 mg-only semaglutide and sustained 2.5 mg-only tirzepatide exposures as real-world proxies for “microdosing” and analyzed de-identified electronic hea…

Background: Nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by renal resistance to arginine vasopressin, most commonly caused by pathogenic variants in the AVPR2 gene. While X-linked NDI classically affects males, heterozygous females may exhibit variable clinical expression. Certain AVPR2 variants are associated with partial NDI and milder phenotypes. Methods: We conducted …

Understanding variations in hospitals’ operational performance and patient safety is critical for improving health system efficiency, particularly in decentralized healthcare systems such as that of Indonesia. While geographic disparities in health outcomes are often emphasized in research, the relative contribution of spatial patterns remains underexplored. Addressing this gap, this study analyz…

Purpose: This study investigates how financial and entrepreneurial capability configurations differentiate internationalized from domestically oriented Thai SMEs. By adopting a decision‐science perspective, the study identifies the capability patterns that shape firms’ strategic international orientation. Design/methodology/approach: This research, which utilizes survey and financial data from 17…

Globally, it is estimated that the number of light duty vehicles will increase, with the potential to reach 2 billion by 2040, and that petrol, including biofuel additives such as ethanol, will continue to be used in substantial quantities for road transport applications until at least 2050. The main focus of vehicle manufacturers today is to ensure their future product ranges are compatible with…

Soil microorganisms and plant residue decomposition are critical drivers of soil nutrient cycling and multifunctionality, yet their regulatory mechanisms in saline-alkali soils are not fully understood. This study selected bare land and forestland (shrub and tree stands) in Daqing, Heilongjiang, to investigate the effects of plant residue input on forest soil properties, microbial communities, ke…

Social media generate massive amounts of unstructured, multilingual textual data that contain many sentiments, emotions and opinions from users that provide insights for enterprises undergoing digital transformation. In this paper, we evaluate a variety of commercially available, lightweight Large Language Models (LLMs) for sentiment, emotion, aspect-based sentiment, and toxic speech detection on…

Increasing atmospheric CO2 concentration can enhance plant photosynthesis and promote plant growth, thereby affecting the N cycle. To investigate the effects of long-term elevated atmospheric CO2 concentration (eCO2) and N deposition on N absorption and distribution in Calamagrostis angustifolia wetlands in the Sanjiang Plain, this study was conducted in open-top chambers (OTC-1) with 15 years of…

Backround: Musculoskeletal disorders associated with muscular strain on the neck and shoulders affect women in administration more often than men. Ergonomic guidelines have historically been derived from male models, often ignoring biomechanical differences between the sexes. The study aims to quantify the acute biomechanical response of the neck muscles of men and women to a standardized writing…

Objectives: Streptococcus pneumoniae is a major respiratory pathogen. Reports during the COVID-19 era suggest decreased pneumococcal activity. This study aimed to assess the frequency of S. pneumoniae in adult sputum cultures and its antimicrobial susceptibility in a tertiary care hospital. Materials and Methods: This retrospective laboratory-based study was conducted in a tertiary care hospital …

The rapid expansion of wearable fitness devices has generated an unprecedented volume of personal health data, promoting self-awareness and helping users make healthier lifestyle decisions. Artificial intelligence (AI) is increasingly being embedded in wearable fitness devices, thereby turning passive self-monitoring into personalised coaching with adaptable goals, real-time feedback, and behavio…

Background: Transmasculine people face distinct challenges in accessing and using contraceptive methods, influenced by gendered embodiment, healthcare systems, and identity-driven decision-making. UK-based qualitative research on this topic is minimal. This study aims to gain a deeper insight into the factors that influence transmasculine people's experiences of contraceptive methods and…

Collagen-based biomaterials possess many advantages, such as low immunogenicity, biodegradability, biocompatibility, hydrophilicity, and ease of processability. Nevertheless, natural collagen has inherent limitations as an in vivo scaffold, including insufficient mechanical strength, low thermal stability, and low resistance to enzymatic degradation. To overcome these drawbacks, various approache…

Addressing the century-old problem of turbulent intermittency, we present a rigorous parameter-free derivation of the scaling exponents for turbulent longitudinal structure functions, based on the ϕ(τ) spacetime and the physical upper bound of Lagrangian micro-rotation velocity ΩFluidMAX. For the low-order regime (p≤6), the derived strict quadratic formula reads: ζp=p/3+p(3−p)/8π^2. This formula …

Contemporary ESG (Environmental, Social, and Governance) regulation creates costs and risks for businesses, which are associated with the stringency of requirements. This article demonstrates that the key source of these problems is the fragmentation of legal regulation, the inconsistency of reporting standards, and the methodological heterogeneity of ESG indices. Based on a comparative legal ana…

Background: The clinical outcomes of lung cancer brain metastases (LCBMs) are highly variable. Traditional pathology relies on bulk cell densities. These static measures fail to capture the spatial architecture of the tumor immune microenvironment (TIME). B7-H3 (CD276) represents a key immune checkpoint in LCBMs. We investigated whether the spatial orchestration of B7-H3-expressing cell populatio…

We give a single, self-contained and fully audited account of the analytic programme on therestricted weighted Goldbach sum Ra,q(N) = sum_{p1+p2=N, p1≡a (mod q)} (log p1)(log p2),Ma,q(N) = C2 S(N)/phi(q) * N, and its exceptional set Ea,q(X) = {N ≤ X, N even: Ra,q(N) = 0}. -Part I (Unconditional core). We establish, with complete proofs and certified numericalconstants: an effective almost-all the…

We present newly derived approximate analytical solutions of the motion, free and forced modes of dynamics of two viscoelastic rheological Maxwell-Faraday discrete dynamic systems, creeper type, and fractional type, with piezoelectric polarization property of the Faraday piezoelectric element. New theoretical analytical scientific results of research into the creep dynamics of basic rheological M…

This study explores the impact of physical activity on psychological well-being in older adults, emphasizing the different roles of social relationships. Utilizing data from the 2020 Korean National Survey of Older Persons, we applied structural equation modeling to analyze both direct and indirect pathways connecting physical activity to well-being through social contact and emotional support. T…

Automated corrosion inspection is essential in the maritime industry, where continuous monitoring of ship hulls and docking infrastructure is necessary to ensure operational safety and structural reliability. However, many existing predictive and deep learning-based approaches depend heavily on large annotated datasets, extensive training procedures, and substantial computational resources, limit…