Preprints.org

Purpose: To describe short- and long-term visual outcomes after MAIA microperimetry Biofeedback Training (BT) in a low-vision rehabilitation cohort. Methods: Retrospective study of patients who completed BT between 2017 and 2023 (4.1 ± 0.6 sessions). The MAIA device recorded P1 and P2 parameters, defined as the percentage of fundus-tracked fixation points falling within device-defined circular wi…

For the intersection of two disks meeting at angle 2α, let C(α) be the least constant in the associated spectral-set inequality, uniformly over operators for which each disk separately is a spectral set. The exact value of C(α) is unknown except at the disk endpoint α = π/2. We give a self-contained Möbius reduction to the corresponding numerical-range problem on a sector and compute the sharp co…

Background/Objectives. Mobile phone-based vaccination interventions, including SMS reminders, voice calls and tracking applications, have repeatedly shown effectiveness in controlled settings across sub-Saharan Africa. Many nevertheless stop operating once project funding ends and do not become part of the routine health systems they were intended to strengthen. This study aimed to develop a prel…

Based on Information Processing Theory (IPT), this study examines the impact of suppliers’ digital transformation (SDT) on focal firms’ green innovation (FGI) through supply chain information processing. From an information processing perspective, it identifies three boundary conditions: geographical distance, environmental regulation intensity, and analyst attention, and further analyzes how the…

Large language models (LLMs) have demonstrated strong capabilities across diverse tasks such as language understanding, reasoning, planning, and code generation. However, their sequence-based architectures limit their ability to capture complex relational structures, long-range dependencies, and multi-hop interactions. Graphs, which explicitly model entities and relationships, provide a natural c…

Pseudopus apodus is an anguimorph lizard belonging to the order Squamata. Anatomical information on this species remains limited, particularly regarding soft tissues, and has primarily focused on the axial skeleton of both living and fossil specimens. Recently, the anatomy of its coelomic cavity has been described using dissection and multidetector computed tomography (CT), and its brain has been…

Five new cembrane-type diterpenes (1–5), one new casbane-type diterpene (7), along with ten known related ones (6, 8–16), were isolated from the South China Sea soft coral Sinularia nanolobata. The structures of new compounds were elucidated through comprehensive spectroscopic analysis, NMR calculation with DP4+ probability analysis, time dependent density functional theory-electronic circular di…

Compressible rotational gas–particle flows at high Mach numbers are ubiquitous in advanced powder processing technologies, including cyclone separators, supersonic jet mills, and pneumatic conveying systems. Accurate predictive modelling remains profoundly challenging due to long-range nonlocal particle interactions, anomalous diffusion and viscoelastic memory effects, and shock discontinuities t…

Hidradenitis suppurativa (HS) is a systemic inflammatory skin disease associated with obesity, insulin resistance, and visceral adiposity. Chronic metainflammation may contribute to cutaneous disease activity, while metabolic dysregulation potentially occurs independently of body mass index (BMI). Additionally, emerging metabolic pharmacotherapies may provide weight-dependent and weight-independe…

Learning from prior experience is essential for autonomous robots, but directly reusing historical actions is often insufficient when the environment changes and previously successful behaviors are no longer applicable. This paper proposes an experience-to-thought learning framework that learns the underlying thinking activities behind historical robot materials rather than only their surface beh…

Large Language Models (LLMs) aligned using Reinforcement Learning from Human Feedback(RLHF) are learning what to say from discrete, voluntary preference judgments, but not how their communication lands. The LLM does not know how different answers affect a listener’s cognition and emotion in real time, regardless of how intelligent the model is on benchmark tests. This becomes a major gap in devel…

Battery-powered sensors must sample sparingly to conserve energy while still reconstructing the signal faithfully between measurements, and the decision logic must fit microcontroller-class hardware. We use a large language model (LLM) as an offline policy compiler: given a natural-language task description and a compact rule grammar, it returns policies as a few numeric thresholds and integer pe…

Breast-conserving surgery followed by adjuvant whole-breast irradiation ( WBI) remains the standard of care for patients with early-stage breast cancer. In this setting, irradiation of the tumor bed with an additional boost dose has historically been used to reduce the risk of ipsilateral breast tumor recurrence (IBTR). The major randomized trials established that boost irradiation improves local…

Background/Objectives: This study aimed to explore parents’ response processes and information-seeking patterns regarding early childhood sexuality education by integrating semantic network analysis of digital discourse with in-depth interviews. Methods: A qualitative multimethod design was employed. Semantic network analysis was conducted on 124 online posts from Korean parenting communities and…

Background and Objectives: Extracranial bleeding after intravenous alteplase is less consistently characterized than symptomatic intracranial hemorrhage. This study describes three site-specific manifestations—gingival bleeding, hematuria, and upper gastrointestinal bleeding—documented after alteplase in older adults with acute ischemic stroke. Materials and Methods: This retrospective single-cen…

The common bean (Phaseolus vulgaris L.) is a key crop for food security in Mexico, yet its genetic resources remain poorly characterized in rural areas with high agrobiodiversity. Using genotyping-by-sequencing, we assessed genetic diversity, population structure, and gene flow among wild populations (W), traditional landraces (L), and commercial varieties exchanged through local markets (M), con…

Exosomes are small vesicles released by various cells type; compounds of a lipid bilayer and surface proteins that facilitate their recognition, direction and uptake by the target cell. Inside, exosomes contain proteins, lipids, and nucleic acids, the composition of which varies depending on the cell of origin. Exosomes can be internalized by the target cell by endocytosis, fusion, or ligand-rece…

Hospital pharmacy replenishment decisions are made under demand uncertainty, where stockouts may compromise service continuity and overstock may immobilize scarce resources. This study proposes a demand-profile-informed framework for selecting probabilistic inventory models for medication supply decisions. Monthly demand records and consolidated operational cost parameters for 13 medicines over 4…

This study analyzes the evolution of chair design in the Argentine Republic as a sequence of paradigmatic transformations analogous to those described by Thomas S. Kuhn in The Structure of Scientific Revolutions. Through a qualitative hermeneutic approach, it examines three emblematic cases — the matera chair, the B.K.F. chair, and the Aro chair — all situated within the American Liberal Social O…

Background and Objectives: Cell-free immune-conditioned products can preserve biological complexity while enabling standardized manufacture, repeated low-volume administration, and mechanism-linked testing. This review developed a source-aware framework for their translation in advanced solid tumors. Materials and Methods: PubMed/MEDLINE, consensus statements, profession-al-society documents, reg…