Purpose: To describe short- and long-term visual outcomes after MAIA microperimetry Biofeedback Training (BT) in a low-vision rehabilitation cohort. Methods: Retrospective study of patients who completed BT between 2017 and 2023 (4.1 ± 0.6 sessions). The MAIA device recorded P1 and P2 parameters, defined as the percentage of fundus-tracked fixation points falling within device-defined circular windows centered on the trained retinal locus (TRL). Outcomes: baseline, short-term follow-up (< 6 months), and long-term follow-up (≥6 months): best-corrected distance visual acuity (BCVA), near visual acuity, fixation stability (BCEA), mean retinal sensitivity (dB), and reading speed (wpm) MNRead app. Results: 346 participants studied. Performance increased: median P1 from 21.5% in session 1 to 32% in session 5, P2 from 66% in session 1 to 81.5% in Session 5. BCVA increased from baseline to short-term follow-up (median 0.40 to 0.30 logMAR; F(2,797)=14.04, p< 0.0001), long-term follow-up did not. Near vision had an improvement (F(2,770)=8.54, p< 0.0001) but no long-term difference from baseline (p=0.0563). In a secondary analysis excluding eyes with documented disease progression, improvements in both distance and near vision were sustained at the long-term follow-up. This finding suggests that disease progression likely attenuated the long-term effect in the full cohort. Conclusions: BT led to significant short-and- long term functional gains in the absence of disease progression. Given the retrospective design, these findings remain hypothesis-generating evidence supporting further studies.
Short- and Long-Term Outcomes After MAIA-Guided Biofeedback Training in 346 Patients with Low Vision: A Retrospective Cohort Study
Mariana AM Misawa·Monica Daibert-Nido·Aljeena Rahat Qureshi·Ghaliah Nsour·Tina Felfeli·Samuel Markowitz

