A novel bacterial strain, CR191T, was isolated from maize (Zea mays) rhizosphere soil. The strain is Gram-stain-negative, oxidase-positive, rod-shaped, non-motile, and aerobic. Phylogenetic analysis based on 16S rRNA gene sequences placed CR191T within the genus Dyella, with highest similarity to Dyella flava DHOC52T (98.23%) and Dyella dinghuensis DHOA06T (98.16%). The genomic DNA G+C content was 66.19%. Average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain CR191T and the type strains of the other 36 validly published Dyella species ranged from 79.0 to 86.6% and 20.2–28.7%, respectively, both below the recognized thresholds for species delineation. Genome mining identified several putative biosynthetic gene clusters showing similarity to known clusters associated with diverse secondary metabolites, including saframycin, cosmomycin, and malleobactin biosynthesis. The major cellular fatty acids were iso-C17:0, iso-C15:0, and summed feature 9 (comprising iso-C17:1 ω9c and/or C16:0 10-methyl). The polar lipid profile comprised phosphatidylglycerol, phosphatidylethanolamine, phosphatidylmonomethylethanolamine and two unidentified polar lipids; the sole respiratory quinone was ubiquinone Q-8. Based on a combination of phenotypic, chemotaxonomic, genomic, and phylogenetic characteristics, strain CR191T is considered to represent a novel species of the genus Dyella, for which the name Dyella cornirhiza sp. nov. is proposed. The type strain is CR191T (=CCAM 2032T = JCM 36807T).