Patient navigation is generally defined as an individualized service that breaks down barriers to provide comprehensive and equitable cancer care. As the evidence base grows for patient navigation efficacy in diverse settings across the cancer continuum, navigation is increasingly recognized and adopted as an essential resource to aid in linking to and advocating for patient-centered services. To further patient navigation as a core component of cancer care, the American Cancer Society formed the Global Alliance for Cancer Patient Navigation to build awareness, evidence, and momentum and to coalesce around the core principles to aid sustainable implementation, keeping the voiced needs of people with lived experience at the forefront.