Formulation and Evaluation of Clopidogrel Bisulfate Sustained Release Matrix Tablets by Melt Granulation Technique

The present research work focuses on the formulation and evaluation of sustained release matrix tablets of Clopidogrel bisulfate using the melt granulation technique. The main objective of the study was to prolong drug release, enhance patient compliance, and maintain constant therapeutic levels. Clopidogrel, an antiplatelet agent with a short biological half-life, requires frequent dosing; hence, a sustained release formulation was designed to overcome this limitation. In this study, a total of