Introduction Traumatic brain injury (TBI) is a leading cause of mortality and long-term disability worldwide, producing acute neurological deficits and lasting cognitive impairment. Post-injury neuroinflammation is a principal driver of secondary damage and contributes substantially to TBI-induced cognitive dysfunction (TBI-CD), yet the cell-autonomous mechanisms operating within neurons remain incompletely characterised. The AIM2 inflammasome — a cytosolic sensor of double-stranded DNA that dri
A self-perpetuating neuron-intrinsic GSDMD–mtDNA–AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury
T Li·Jiangtao Sheng·Junjun Zhang·Xueer Liu·Lihong Zhu·Y K Li·Runmin Lin·Xiaoxuan Chen·Kangsheng Li·W Chen·Siyu Huang