Hydrogen sulfide donor sodium hydrosulfide modulates ovarian steroidogenesis and follicular integrity in a DHEA-induced rat model of polycystic ovary syndrome

Background Hydrogen sulfide (H 2 S) has emerged as a potential regulator of ovarian physiology; however, its role in polycystic ovary syndrome (PCOS) remains incompletely understood. This study aimed to investigate the effects of the H 2 S donor sodium hydrosulfide (NaHS) on ovarian steroidogenesis, apoptosis and follicular remodelling in a dehydroepiandrosterone (DHEA)-induced rat model of PCOS. Methods Thirty adult female Wistar rats were randomly assigned to control, vehicle, PCOS, NaHS, and