Xeroderma Pigmentosum with Multiple Cutaneous Malignancies: A Series of Four Cases

Xeroderma Pigmentosum (XP) is an autosomal recessive disease. The pathogenesis lies in the Nucleotide Excision Repair (NER) genetic defect leading to various cutaneous and other malignancies developing at a very young age alarming the identification of precursor lesions and to adapt preventive measures. The DNA damage that occurs in exposure to UV rays in sunlight, gets repaired by a set of XP genes. The function of each gene works in a coordinated manner and the defective nucleotide gets excise