Cissus quadrangularis is a medicinal plant with a wide range of traditional uses as an Ayurvedic herb for the treatment of fractures and musculoskeletal problems. Recent research has emphasised the evaluation of the therapeutic potential of the plant by conducting human clinical trials. This review aims to provide an overview of the current evidence of the use of Cissus quadrangularis in maintaining bone health, particularly with respect to biomarkers, fractures, and osteoporosis. Clinical and b