Zenodo (CERN European Organization for Nuclear Research)

Adenomyosis is a benign uterine disorder characterized by ectopic endometrial tissue within the myometrium, resulting in uterine enlargement, chronic inflammation, and fibrosis. It typically presents with heavy menstrual bleeding, dysmenorrhea, pelvic pain, and infertility, although some cases may remain asymptomatic. With advancements in imaging techniques such as transvaginal ultrasonography an…

Maintaining compliance throughout the entire product lifecycle is essential for contemporary pharmaceutical quality systems. This process encompasses all stages, starting from the initial product development to commercial manufacturing, overseeing post-approval lifecycles, and ultimately the discontinuation of products. The pharmaceutical sector is progressively embracing a Quality Assurance (QA)…

Task-oriented conversational AI deployments in edge environments face a constraint combination that existing architectures address only partially: persistent operational memory without cloud retraining, sub-second response latency on commodity hardware, structural privacy enforcement, and direct physical-world actuation. This paper presents Context-Gated Pattern Accumulation (CGPA) as a Design Sc…

Cissus quadrangularis is a medicinal plant with a wide range of traditional uses as an Ayurvedic herb for the treatment of fractures and musculoskeletal problems. Recent research has emphasised the evaluation of the therapeutic potential of the plant by conducting human clinical trials. This review aims to provide an overview of the current evidence of the use of Cissus quadrangularis in maintain…

Time is a fundamental, yet often overlooked, regulator of human physiology. Contemporary biomedical research has demonstrated that biological processes follow intrinsic rhythmic patterns, particularly circadian rhythms, which regulate the sleep–wake cycle, hormonal secretion, metabolism, immune responses, and cognitive function. Disturbances in these rhythms are strongly associated with lifestyle…

Cynodon dactylon, a tropical grass has been traditionally used in folk medicine to treat various ailments. The present study aimed to extract the root part of Cynodon dactylon and evaluate the anticoagulant activity. The extract was prepared by using maceration method with aqueous & non aqueous solvent and evaluation of it’s anticoagulant activity by using blood clotting time measurement method. …

The medical community has struggled to better understand and treat the complexity of cancer, which is the second leading cause of death worldwide, responsible for one in every six deaths (world health organization). It discusses the use of AI in medical oncology, such as how AI is used in treatment decision-making for adult and pediatric cancer care, and how applications like advanced imaging, dr…

Ageing is the process during which structural and functional changes accumulate in an organism as a result of the passage of time. The changes manifest as a decline from the organism's peak physiological functions. Ageing is biological clock of all human body. Presbyacusis is an hidden disability, one among the many socio-medical problems. The hearing impairment in elderly people is described as …

Background: LLMs have recently received considerable attention as potential applications within the realm of healthcare, notably pharmacy practice and databases of medications information. However, the utility of LLMs in a clinical context is severely limited due to the possible generation of factually untrue or invented output that is highly risky to patients' safety. Objectives: In this paper, …

Diabetic neuropathy remains one of the most frequent and disabling complications of diabetes mellitus, affecting a substantial proportion of patients and imposing a heavy burden on quality of life. In Ayurveda, this condition is not explicitly named as a single disease entity; rather, its manifestations—such as numbness, tingling, burning sensations, and muscle wasting—are described as prodromal …

Background: In contemporary medicine, antimicrobial drugs are the cornerstone of treatment. Antibiotic resistance results from the inappropriate prescription of antibiotics. The World Health Organization (WHO) created the WHO AWaRe categorization of antibiotics and core prescribing indicators. It is necessary to comprehend antibiotic stewardship and prescription practices. The current study audit…

The Ayurvedic philosophy of Ritucharya focuses on seasonal adaptation to maintain balance between Doshas, Agni, Dhatus, and general health. The summer season, known as Grishma Ritu, is distinguished by extreme heat, aridity, and diminished physical vigor as a result of the prevalence of Adana Kala. The body loses more fluids, has less Kapha, has a slow buildup of Vata, and has a weaker digestive …

Grahani Roga is a chronic gastrointestinal disorder characterized by impairment of Agni resulting in defective digestion, absorption, and assimilation of nutrients. Persistent Agni Dushti leads to formation of Ama, Srotorodha, and Dhatu Kshaya, ultimately affecting Asthi Dhatu and predisposing individuals to osteopenia and osteoporosis.[1,2] Ayurveda emphasizes the physiological relationship betw…

Miconazole nitrate, an antifungal agent, is widely used for the treatment of various fungal infections. The development of topical patches as a delivery system for miconazole nitrate aims to enhance localized drug delivery, minimize systemic absorption, and improve patient compliance. This study focuses on the formulation and evaluation of miconazole nitrate topical patches using a solvent castin…

Background: Ptosis, defined as drooping of upper eyelid, can be congenital or acquired. Traumatic ptosis is an acquired condition resulting from injury to the Levator palpebral superioris muscle, its aponeurosis, or associated neurogenic structures. It affects both functional vision and Facial appearance. Timely diagnosis and appropriate classification are essential for effective management and t…

Melanoma is an aggressive type of skin cancer that has high metastatic ability and resists standard therapies such as radiotherapy, chemotherapy, and targeted therapy. Although, signific ant advancements have been achieved in the evolving field of immunotherapy especially immune checkpoint inhibitors; several hurdles including heterogeneous response and treatment resistance are still challenging …

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) represent a transformative pharmacological class simultaneously addressing two major global health burdens: type 2 diabetes mellitus (T2DM) and obesity. This review synthesizes and compares clinical evidence from randomized controlled trials, systematic reviews, meta-analyses, and cardiovascular outcome trials published between 201…

Human organ transplantation stands out as one of the most significant life-saving medical breakthroughs of the modern era. However, the widening gap between the clinical demand for organs and their available supply has created a lucrative environment for severe medico-legal vulnerabilities and transnational crime. This review article explores the multifaceted legal landscape and systemic ethical …

Today, Modern medical science, have lots of facilities and upgraded technologies for treatment portion of patient, even though many diseases may still in progressive phase in the society. Psoriasis is one of such kind of disorders, which has substantial psychological and social impact on a patient’s life. Being skin manifestations psoriasis goes beyond a cosmetic problem. Psoriasis is a non-infec…

Despite significant investment in drug discovery, Alzheimer's disease (AD) continues to be a significant unmet medical need. The effectiveness of CNS drugs is severely hampered by the blood-brain barrier (BBB), and many potential compounds fall short because of poor ADMET characteristics or insufficient brain exposure. Key research gaps on BBB-crossing compounds for AD are identified in this revi…